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Thus, FOXO4-DRI selectively induces apoptosis in senescent cells without adversely affecting normal cells, providing new strategies and approaches to address the accumulation of senescent cells

A dose-dependent effect has also been observed, with a 7% increase in the overall risk of death for every five pack-years increase in smoking history [113]

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These findings exhibited that EGb may facilitate improvements in sleep continuity and non-REM sleep among individuals with depression, potentially via the modulation of corticotropin-releasing hormone (CRH) activity, thereby presenting a promising adjunctive approach for the management of sleep disturbances associated with depression (69)

Lam TP, Lee T-M, Chen C-Y, Chang J-S